Evidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 11 studies
Evidence Intelligence for Diabetes
Organizing diabetes research into clear, evidence-based insights powered by the Evidence Intelligence™ framework.
Explore thousands of research-backed evidence relationships, compare interventions, and discover what the evidence says. Create a free workspace to organize your research, share curated evidence with others, and stay informed as new studies are published.
Evidence Intelligence
447
Studies Analyzed
2,362
Evidence Relationships
292
Interventions Tracked
897
Outcomes Modeled
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Learn about Evidence Intelligence™Your evidence doesn't stop at discovery
Your Evidence Workspace
Save evidence, organize collections, share research, and stay informed as new evidence emerges.
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Explore Diabetes Evidence Topics
Deep dives into key evidence areas with comprehensive research synthesis
Outcome topic
Evidence related to lowering or improving HbA1c/A1C in diabetes management.
173 Studies
Outcome topic
Evidence related to body weight reduction, BMI improvement, waist circumference, and body composition changes.
102 Studies
Outcome topic
Evidence related to blood glucose control, fasting glucose, postprandial glucose, glucose variability, and time in range.
117 Studies
Evidence topic
Evidence related to improving insulin resistance, insulin sensitivity, fasting insulin, C-peptide levels, and beta-cell function in diabetes and prediabetes.
19 Studies
Evidence topic
Evidence related to preventing or delaying type 2 diabetes, reducing diabetes incidence, and improving metabolic risk in people with prediabetes.
18 Studies
Evidence topic
Evidence related to diabetic kidney disease, albuminuria, kidney function, nephropathy progression, end-stage renal disease, and kidney-protective diabetes treatments.
9 Studies
How Diabetes Evidence Connects
Every study contributes evidence linking interventions and outcomes. deDiabetes organizes those findings into connected evidence topics so you can move from broad questions to supporting research.
Intervention
Physical Activity
↓
Outcome
HbA1c Reduction
Intervention
Metformin
↓
Outcome
Glycemic Control
Intervention
CGM
↓
Outcome
Time in Range
292
Interventions
897
Outcomes
2,362
Evidence Relationships
connected findings
Build and Share Evidence Collections
Create curated evidence collections and share them with anyone using a public link—no account required to view.
Top Evidence Signals
15 pairs
Highest-ranked evidence pairs currently in database
Preview:
- •Semaglutide → Body weight
- •Semaglutide → HbA1c
Explore collection
Most Consistent Results
109 pairs
Evidence with agreement across multiple studies
Preview:
- •Metformin → Fasting Plasma Glucose (FPG)
- •Metformin → HbA1c
Explore collection
Most Studied Interventions
277 pairs
Interventions with the broadest evidence base
Preview:
- •Vitamin D supplementation
- •Semaglutide
Explore collection
Emerging Evidence
View
Promising early-stage research areas
Explore collection
New Evidence This Month
View
Recently published research
Explore collection
What sharing looks like
Share evidence with the people who matter
Send one organized evidence resource to your physician, dietitian, family, or research colleagues.
Public Collection
Weight Loss Evidence
dediabetes.com/shared/your-collection
Anyone can explore without an account.
Shared withPhysicianFamilyResearch team
Featured Evidence Insights
Strongest findings from our evidence intelligence analysis
Grouped evidence
GLP-1 Receptor Agonists → HbA1c
Semaglutide → HbA1c
Semaglutide shows strong improvement in HbA1c with consistent results (well-studied, 13 studies).
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 13 studies
View evidenceGrouped evidence
GLP-1 Receptor Agonists → Body Weight
Semaglutide → Body weight
Semaglutide shows moderate improvement in Body weight with consistent results (well-studied, 11 studies).
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 11 studies
View evidenceGrouped evidence
GLP-1 Receptor Agonists → HbA1c
Tirzepatide → HbA1c
Tirzepatide shows strong improvement in HbA1c with consistent results (well-studied, 9 studies).
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 9 studies
View evidenceGrouped evidence
Metformin Therapies → HbA1c
Metformin → HbA1c
Metformin shows moderate improvement in HbA1c with consistent results (emerging research, 7 studies).
Evidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 86
- consistent
Supporting studies: Based on 7 studies
View evidenceGrouped evidence
GLP-1 Receptor Agonists → Body Weight
Tirzepatide → Body weight
Tirzepatide shows strong improvement in Body weight with consistent results (emerging research, 8 studies).
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 8 studies
View evidenceGrouped evidence
Insulin Delivery Systems → CGM Time in Range
Hybrid closed-loop system → Time in range
Hybrid closed-loop system shows strong improvement in Time in range with consistent results (emerging research, 8 studies).
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 72
- Positive
- ConsistencyScore™
- 73
- generally_consistent
Supporting studies: Based on 8 studies
View evidenceLiving Evidence
Always Up to Date
New studies continuously strengthen, refine, or challenge existing evidence. Follow what matters and see what's changed.
20
New studies this week
99
New relationships this week
3
Evidence changes this week
Latest Research
Evidence Comparison Table
Highest-ranked intervention and outcome relationships
Ranked by EvidenceScore™
| # | Intervention | Outcome | EvidenceScore™ | ImpactScore™ | Consistency | Studies | Effectiveness |
|---|---|---|---|---|---|---|---|
| 1 | Semaglutide | Body weight | 88/100Strong | 83/100Positive | 96/100consistent | 11 | Moderate Positive |
| 2 | Semaglutide | HbA1c | 87/100Strong | 93/100Very Positive | 93/100consistent | 13 | Strong Positive |
| 3 | Tirzepatide | HbA1c | 85/100Strong | 93/100Very Positive | 93/100consistent | 9 | Strong Positive |
| 4 | Metformin | HbA1c | 85/100Strong | 83/100Positive | 86/100consistent | 7 | Moderate Positive |
| 5 | Tirzepatide | Body weight | 84/100Strong | 83/100Positive | 96/100consistent | 8 | Strong Positive |
| 6 | SMS text messaging behavioral intervention for health promotion | HbA1c | 83/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 6 | Weak Positive |
| 7 | Vitamin D supplementation | HbA1c | 82/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 5 | Moderate Positive |
| 8 | Dapagliflozin | HbA1c | 81/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 5 | Moderate Positive |
| 9 | Hybrid closed-loop system | Time in range | 81/100Strong | 72/100Positive | 73/100generally_consistent | 8 | Strong Positive |
| 10 | Hybrid closed-loop system | HbA1c | 80/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 5 | Strong Positive |
| 11 | Vitamin D supplementation | Fasting Plasma Glucose (FPG) | 79/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 3 | Neutral |
| 12 | Liraglutide | Body weight | 79/100Strong | 83/100Positive | 96/100consistent | 4 | Moderate Positive |
Evidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 11 studies
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 13 studies
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 9 studies
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 86
- consistent
Supporting studies: Based on 7 studies
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 8 studies
SMS text messaging behavioral intervention for health promotion → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
Supporting studies: Based on 6 studies
Vitamin D supplementation → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
Supporting studies: Based on 5 studies
Dapagliflozin → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 81
- Strong
Supporting studies: Based on 5 studies
Evidence Intelligence™
- EvidenceScore™
- 81
- Strong
- ImpactScore™
- 72
- Positive
- ConsistencyScore™
- 73
- generally_consistent
Supporting studies: Based on 8 studies
Hybrid closed-loop system → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 80
- Strong
Supporting studies: Based on 5 studies
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
Supporting studies: Based on 3 studies
Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 4 studies
How to Read Evidence Cards
Understanding an Evidence Card
Every Evidence Card summarizes one intervention-outcome relationship using Dediabetes' Evidence Intelligence system: ImpactScore™, EvidenceScore™, ConsistencyScore™, supporting study count, and direct access to the underlying evidence.
Example Evidence Card
GLP-1 receptor agonists → HbA1c
Current evidence suggests a positive impact on HbA1c with strong supporting evidence and generally consistent findings across studies.
Evidence Intelligence™
- EvidenceScore™
- 70
- Moderate
- ImpactScore™
- 82
- Positive
- ConsistencyScore™
- 89
- Consistent
Supporting studies: Based on 11 studies
View evidence1
Relationship
Intervention → Outcome. The evidence relationship being summarized.
2
Evidence Summary
A plain-language summary of what the evidence suggests.
3
ImpactScore™
ImpactScore™ summarizes what impact the current evidence suggests.
4
EvidenceScore™
EvidenceScore™ summarizes how much confidence to place in that conclusion.
5
ConsistencyScore™
ConsistencyScore™ summarizes how consistently independent studies reach the same conclusion.
6
Supporting Studies
Number of studies contributing to this evidence relationship.
7
Call to Action
Open the full evidence page for supporting studies, methodology, and related evidence.
ImpactScore™, EvidenceScore™, and ConsistencyScore™ are generated by the Evidence Intelligence system and are not medical advice.
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