Organizing diabetes research into clear, evidence-based insights powered by the Evidence Intelligence™ framework.
Understand diabetes research—without reading every study
| Intervention | Outcome | EvidenceScore™ |
|---|---|---|
| Semaglutide | HbA1c | 87 |
| Metformin | HbA1c | 85 |
| Tirzepatide | HbA1c | 85 |
Deep dives into key evidence areas with comprehensive research synthesis
Evidence related to lowering or improving HbA1c/A1C in diabetes management.
Evidence related to body weight reduction, BMI improvement, waist circumference, and body composition changes.
Evidence related to blood glucose control, fasting glucose, postprandial glucose, glucose variability, and time in range.
Evidence related to improving insulin resistance, insulin sensitivity, fasting insulin, C-peptide levels, and beta-cell function in diabetes and prediabetes.
Evidence related to preventing or delaying type 2 diabetes, reducing diabetes incidence, and improving metabolic risk in people with prediabetes.
Evidence related to diabetic kidney disease, albuminuria, kidney function, nephropathy progression, end-stage renal disease, and kidney-protective diabetes treatments.
Every study contributes evidence linking interventions and outcomes. deDiabetes organizes those findings into connected evidence topics so you can move from broad questions to supporting research.
Strongest findings from our evidence intelligence analysis
Semaglutide → Body weight
Semaglutide shows moderate improvement in Body weight with consistent results (well-studied, 10 studies).
Semaglutide → HbA1c
Semaglutide shows strong improvement in HbA1c with consistent results (well-studied, 11 studies).
Tirzepatide → HbA1c
Tirzepatide shows strong improvement in HbA1c with consistent results (well-studied, 9 studies).
Metformin → HbA1c
Metformin shows moderate improvement in HbA1c with consistent results (emerging research, 7 studies).
Tirzepatide → Body weight
Tirzepatide shows strong improvement in Body weight with consistent results (emerging research, 8 studies).
Liraglutide → Body weight
Liraglutide shows moderate improvement in Body weight with consistent results (emerging research, 4 studies).
High-value evidence organized by ImpactScore™, EvidenceScore™, ConsistencyScore™, and research focus
Highest-ranked evidence pairs currently in database
Evidence with agreement across multiple studies
Interventions with the broadest evidence base
Promising early-stage research areas
Recently published research
Recently added studies and evidence pairs
Highest-ranked intervention and outcome relationships from the evidence graph
Ranked using EvidenceScore™, validation, ConsistencyScore™, and study depth
| # | Intervention | Outcome | Effectiveness | EvidenceScore™ | Studies |
|---|---|---|---|---|---|
| 1 | Semaglutide | HbA1c | strong_positive | 87 | 0 |
| 2 | Semaglutide | Body weight | moderate_positive | 87 | 0 |
| 3 | Metformin | HbA1c | moderate_positive | 85 | 0 |
| 4 | Tirzepatide | HbA1c | strong_positive | 85 | 0 |
| 5 | Tirzepatide | Body weight | strong_positive | 84 | 0 |
| 6 | SMS text messaging behavioral intervention for health promotion | HbA1c | weak_positive | 83 | 0 |
| 7 | Vitamin D supplementation | HbA1c | moderate_positive | 82 | 0 |
| 8 | Dapagliflozin | HbA1c | moderate_positive | 81 | 0 |
| 9 | Semaglutide | BMI | moderate_positive | 79 | 0 |
| 10 | Liraglutide | Body weight | moderate_positive | 79 | 0 |
| 11 | Hybrid closed-loop system | HbA1c | strong_positive | 74 | 0 |
| 12 | Hybrid closed-loop system | Time in range | strong_positive | 69 | 0 |
How to Read Evidence Cards
Every Evidence Card summarizes one intervention-outcome relationship using Dediabetes' Evidence Intelligence system: ImpactScore™, EvidenceScore™, ConsistencyScore™, supporting study count, and direct access to the underlying evidence.
Current evidence suggests a positive impact on HbA1c with strong supporting evidence and generally consistent findings across studies.
Intervention → Outcome. The evidence relationship being summarized.
A plain-language summary of what the evidence suggests.
ImpactScore™ summarizes what impact the current evidence suggests.
EvidenceScore™ summarizes how much confidence to place in that conclusion.
ConsistencyScore™ summarizes how consistently independent studies reach the same conclusion.
Number of studies contributing to this evidence relationship.
Open the full evidence page for supporting studies, methodology, and related evidence.
ImpactScore™, EvidenceScore™, and ConsistencyScore™ are generated by the Evidence Intelligence system and are not medical advice.
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