Outcome topic
Evidence related to lowering or improving HbA1c/A1C in diabetes management.
249 Studies
Diabetes evidence, synthesized.
Organizing diabetes research into clear, evidence-based insights powered by the Evidence Intelligence™ framework.
Start with a clinical question and see what the evidence says, or explore the underlying research yourself. Every conclusion stays connected to the studies behind it.
Explore Clinical Reference See synthesized evidence by outcome and intervention.Explore Evidence Browse evidence topics, studies, and research relationships.
Evidence Intelligence
713
Studies Analyzed
3,668
Evidence Relationships
426
Interventions Tracked
1,216
Outcomes Modeled
No subscription required to explore the evidence.
Clinical Reference
Glycemic Control
What does the evidence say?
Structured clinical evidence organized around outcomes, interventions, assertions, and the studies behind them.
23
Evidence assertions
112
Included studies
Clinical Reference turns many studies into structured clinical evidence you can inspect.
Explore Clinical ReferenceWhat does the evidence say?
Clinical Reference
Start with an outcome or intervention and examine the evidence as a structured clinical reference—not as a list of individual studies.
- 1Choose a clinical topic
- 2Review evidence assertions
- 3Examine interventions and outcomes
- 4Inspect supporting studies
Clinical Reference
Cardiovascular Risk
5
Evidence assertions
37
Included studies
Explore the evidence by intervention, assertion, and supporting research.
Explore Clinical ReferenceClinical Reference
Glycemic Control
23
Evidence assertions
112
Included studies
Explore the evidence by intervention, assertion, and supporting research.
Explore Clinical ReferenceClinical Reference
HbA1c Reduction
41
Evidence assertions
195
Included studies
Explore the evidence by intervention, assertion, and supporting research.
Explore Clinical ReferenceExplore Diabetes Evidence Topics
Prefer to explore the research directly? Browse the evidence landscape by diabetes outcome, intervention, and topic.
Outcome topic
Evidence related to body weight reduction, BMI improvement, waist circumference, and body composition changes.
152 Studies
Outcome topic
Evidence related to blood glucose control, fasting glucose, postprandial glucose, glucose variability, and time in range.
169 Studies
Evidence topic
Evidence related to improving insulin resistance, insulin sensitivity, fasting insulin, C-peptide levels, and beta-cell function in diabetes and prediabetes.
26 Studies
Evidence topic
Evidence related to preventing or delaying type 2 diabetes, reducing diabetes incidence, and improving metabolic risk in people with prediabetes.
30 Studies
Evidence topic
Evidence related to diabetic kidney disease, albuminuria, kidney function, nephropathy progression, end-stage renal disease, and kidney-protective diabetes treatments.
8 Studies
How Diabetes Evidence Connects
Every study contributes evidence linking interventions and outcomes. deDiabetes organizes those findings into connected evidence topics so you can move from broad questions to supporting research.
Intervention
Physical Activity
↓
Outcome
HbA1c Reduction
Intervention
Metformin
↓
Outcome
Glycemic Control
Intervention
CGM
↓
Outcome
Time in Range
426
Interventions
1,216
Outcomes
3,668
Evidence Relationships
connected findings
Build and Share Evidence Collections
Create curated evidence collections and share them with anyone using a public link—no account required to view.
Top Evidence Signals
15 pairs
Highest-ranked evidence pairs currently in database
Preview:
- •DSMES → HbA1c
- •Hybrid closed-loop system → Time in range
Explore collection
Most Consistent Results
206 pairs
Evidence with agreement across multiple studies
Preview:
- •Metformin → Glucose iAUC (OGTT)
- •Semaglutide → Adverse events incidence
Explore collection
Most Studied Interventions
325 pairs
Interventions with the broadest evidence base
Preview:
- •Semaglutide
- •Vitamin D supplementation
Explore collection
Emerging Evidence
View
Promising early-stage research areas
Explore collection
New Evidence This Month
View
Recently published research
Explore collection
What sharing looks like
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Send one organized evidence resource to your physician, dietitian, family, or research colleagues.
Public Collection
Weight Loss Evidence
dediabetes.com/shared/your-collection
Anyone can explore without an account.
Shared withPhysicianFamilyResearch team
Featured Evidence Insights
Strongest findings from our evidence intelligence analysis
Grouped evidence
GLP-1 Receptor Agonists → HbA1c
Tirzepatide → HbA1c
Tirzepatide shows strong improvement in HbA1c with consistent results (well-studied, 12 studies).
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 12 studies
View evidenceGrouped evidence
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment shows strong improvement in Periodontal probing depth with consistent results (well-studied, 14 studies).
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 92
- consistent
Supporting studies: Based on 14 studies
View evidenceGrouped evidence
GLP-1 Receptor Agonists → Body Weight
Tirzepatide → Body weight
Tirzepatide shows strong improvement in Body weight with consistent results (well-studied, 11 studies).
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 85
- Very Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 11 studies
View evidenceGrouped evidence
Usual care → HbA1c
Usual care may improve HbA1c with consistent results (well-studied, 10 studies).
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 60
- Slightly Positive
- ConsistencyScore™
- 89
- consistent
Supporting studies: Based on 10 studies
View evidenceGrouped evidence
GLP-1 Receptor Agonists → HbA1c
Semaglutide → HbA1c
Semaglutide shows strong improvement in HbA1c with consistent results (well-studied, 11 studies).
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 11 studies
View evidenceGrouped evidence
SRP + OHI → Periodontal probing depth
SRP + OHI shows strong improvement in Periodontal probing depth with consistent results (emerging research, 7 studies).
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 7 studies
View evidenceLiving Evidence
Always Up to Date
New studies continuously strengthen, refine, or challenge existing evidence. Follow what matters and see what's changed.
0
New studies this week
0
New relationships this week
0
Evidence changes this week
Evidence Comparison Table
Highest-ranked intervention and outcome relationships
Ranked by EvidenceScore™
| # | Intervention | Outcome | EvidenceScore™ | ImpactScore™ | Consistency | Studies | Effectiveness |
|---|---|---|---|---|---|---|---|
| 1 | DSMES | HbA1c | 87/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 8 | Weak Positive |
| 2 | Semaglutide | HbA1c | 86/100Strong | 92/100Very Positive | 93/100consistent | 11 | Strong Positive |
| 3 | Semaglutide | Body weight | 85/100Strong | 85/100Very Positive | 96/100consistent | 9 | Moderate Positive |
| 4 | Metformin | HbA1c | 85/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 11 | Strong Positive |
| 5 | Metformin | Fasting Plasma Glucose (FPG) | 84/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 7 | Moderate Positive |
| 6 | Liraglutide | Body weight | 83/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 5 | Strong Positive |
| 7 | Tirzepatide | HbA1c | 83/100Strong | 92/100Very Positive | 93/100consistent | 12 | Strong Positive |
| 8 | Tirzepatide | Body weight | 83/100Strong | 85/100Very Positive | 96/100consistent | 11 | Strong Positive |
| 9 | Vitamin D supplementation | HbA1c | 82/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 5 | Moderate Positive |
| 10 | Vitamin D supplementation | Fasting Plasma Glucose (FPG) | 79/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 3 | Neutral |
| 11 | Liraglutide | HbA1c | 79/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 3 | Moderate Positive |
| 12 | Metformin | Body weight | 79/100 | Metric not available for this evidence entity | Metric not available for this evidence entity | 3 | Weak Positive |
DSMES → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
Supporting studies: Based on 8 studies
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 11 studies
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
- ImpactScore™
- 85
- Very Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 9 studies
Metformin → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 85
- Strong
Supporting studies: Based on 11 studies
Metformin → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
Supporting studies: Based on 7 studies
Liraglutide → Body weight
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
Supporting studies: Based on 5 studies
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 93
- consistent
Supporting studies: Based on 12 studies
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 85
- Very Positive
- ConsistencyScore™
- 96
- consistent
Supporting studies: Based on 11 studies
Vitamin D supplementation → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
Supporting studies: Based on 5 studies
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
Supporting studies: Based on 3 studies
Liraglutide → HbA1c
Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
Supporting studies: Based on 3 studies
Metformin → Body weight
Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
Supporting studies: Based on 3 studies
How to Read Evidence Cards
Understanding an Evidence Card
Every Evidence Card summarizes one intervention-outcome relationship using Dediabetes' Evidence Intelligence system: ImpactScore™, EvidenceScore™, ConsistencyScore™, supporting study count, and direct access to the underlying evidence.
Example Evidence Card
GLP-1 receptor agonists → HbA1c
Current evidence suggests a positive impact on HbA1c with strong supporting evidence and generally consistent findings across studies.
Evidence Intelligence™
- EvidenceScore™
- 70
- Moderate
- ImpactScore™
- 82
- Positive
- ConsistencyScore™
- 89
- Consistent
Supporting studies: Based on 11 studies
View evidence1
Relationship
Intervention → Outcome. The evidence relationship being summarized.
2
Evidence Summary
A plain-language summary of what the evidence suggests.
3
ImpactScore™
ImpactScore™ summarizes what impact the current evidence suggests.
4
EvidenceScore™
EvidenceScore™ summarizes how much confidence to place in that conclusion.
5
ConsistencyScore™
ConsistencyScore™ summarizes how consistently independent studies reach the same conclusion.
6
Supporting Studies
Number of studies contributing to this evidence relationship.
7
Call to Action
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ImpactScore™, EvidenceScore™, and ConsistencyScore™ are generated by the Evidence Intelligence system and are not medical advice.
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