Browse by outcome

Glycemic Control

Choose an intervention dossier to evaluate the supplied synthesis and supporting evidence.

This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.

40 dossiers158 included studies43 limited studies

40 of 40 dossiers shown

Clinical Reference

Continuous glucose monitoring

Continuous glucose monitoring → Time in range

Continuous glucose monitoring shows a moderate positive evidence signal for improving Time in range across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 8 supporting studies
Open dossier
Clinical Reference

Metformin

Metformin → Fasting Plasma Glucose (FPG)

Metformin shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 7 supporting studies
Open dossier
Clinical Reference

Dipeptidyl peptidase-4 inhibitors

Dipeptidyl peptidase-4 inhibitors → Fasting Plasma Glucose (FPG)

Dipeptidyl peptidase-4 inhibitors shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Metformin

Metformin → Fasting blood sugar (FBS)

Metformin shows a moderate positive evidence signal for improving Fasting blood sugar (FBS) across the studied comparisons.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Empagliflozin

Empagliflozin → Fasting Plasma Glucose (FPG)

Empagliflozin shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Metformin

Metformin → Glucose iAUC (OGTT)

Metformin shows a moderate positive evidence signal for improving Glucose iAUC (OGTT) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 6 supporting studies
Open dossier
Clinical Reference

Semaglutide

Semaglutide → Fasting Plasma Glucose (FPG)

Semaglutide has a small positive evidence signal for Fasting Plasma Glucose (FPG), but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Vitamin D supplementation

Vitamin D supplementation → Blood glucose

Vitamin D supplementation has a small positive evidence signal for Blood glucose, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Very-low-calorie ketogenic diet

Very-low-calorie ketogenic diet → Fasting Plasma Glucose (FPG)

Very-low-calorie ketogenic diet shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Tirzepatide

Tirzepatide → Fasting Plasma Glucose (FPG)

Tirzepatide shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Vitamin D supplementation

Vitamin D supplementation → Fasting Plasma Glucose (FPG)

Vitamin D supplementation has not shown a clear effect on Fasting Plasma Glucose (FPG) in the available evidence.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Insulin therapy

Insulin therapy → Blood glucose

Insulin therapy has a small positive evidence signal for Blood glucose, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Multi-species synbiotic (12 probiotic strains + FOS prebiotic)

Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Fasting Plasma Glucose (FPG)

Multi-species synbiotic (12 probiotic strains + FOS prebiotic) shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Hybrid closed-loop system

Hybrid closed-loop system → Blood glucose

Hybrid closed-loop system shows a moderate positive evidence signal for improving Blood glucose across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Aerobic exercise

Aerobic exercise → Fasting Plasma Glucose (FPG)

Aerobic exercise shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Hybrid closed-loop system

Hybrid closed-loop system → Time above range

Hybrid closed-loop system shows a moderate positive evidence signal for improving Time above range across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Low-carbohydrate diet

Low-carbohydrate diet → 2-hour plasma glucose

Low-carbohydrate diet shows a moderate positive evidence signal for improving 2-hour plasma glucose across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

High-intensity interval exercise

High-intensity interval exercise → Fasting Plasma Glucose (FPG)

High-intensity interval exercise shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Usual care

Usual care → Fasting Plasma Glucose (FPG)

Usual care has not shown a clear effect on Fasting Plasma Glucose (FPG) in the available evidence.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Resistance training

Resistance training → Fasting Plasma Glucose (FPG)

Resistance training shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Aerobic exercise

Aerobic exercise → Blood glucose

Aerobic exercise shows a strong positive evidence signal for improving Blood glucose across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Hybrid closed-loop system

Hybrid closed-loop system → Glucose variability

Hybrid closed-loop system has a small positive evidence signal for Glucose variability, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Continuous glucose monitoring

Continuous glucose monitoring → Time below range

Continuous glucose monitoring has a small positive evidence signal for Time below range, but the clinical interpretation is limited.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Sleeve gastrectomy

Sleeve gastrectomy → Fasting Plasma Glucose (FPG)

Sleeve gastrectomy shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Hybrid closed-loop system

Hybrid closed-loop system → Time in range

Hybrid closed-loop system shows a moderate positive evidence signal for improving Time in range across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 17 supporting studies
Open dossier
Clinical Reference

Control Group Usual Activity

Control Group Usual Activity → Fasting Plasma Glucose (FPG)

Control Group Usual Activity has not shown a clear effect on Fasting Plasma Glucose (FPG) in the available evidence.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Structured multidisciplinary case management

Structured multidisciplinary case management → Fasting Plasma Glucose (FPG)

Structured multidisciplinary case management shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Insulin therapy

Insulin therapy → Time in range

Insulin therapy shows a moderate positive evidence signal for improving Time in range across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Low-carbohydrate diet

Low-carbohydrate diet → Time in range

Low-carbohydrate diet has not shown a clear effect on Time in range in the available evidence.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Time-Restricted Eating (TRE)

Time-Restricted Eating (TRE) → Fasting Plasma Glucose (FPG)

Time-Restricted Eating (TRE) has a small positive evidence signal for Fasting Plasma Glucose (FPG), but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Lifestyle intervention for prediabetes

Lifestyle intervention for prediabetes → 2-hour plasma glucose

Lifestyle intervention for prediabetes has a small positive evidence signal for 2-hour plasma glucose, but the clinical interpretation is limited.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Gastric bypass

Gastric bypass → Fasting Plasma Glucose (FPG)

Gastric bypass shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Lifestyle intervention for prediabetes

Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)

Lifestyle intervention for prediabetes shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Dapagliflozin

Dapagliflozin → Fasting Plasma Glucose (FPG)

Dapagliflozin shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Continuous glucose monitoring

Continuous glucose monitoring → Time above range

Continuous glucose monitoring has a small positive evidence signal for Time above range, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Insulin therapy

Insulin therapy → Glucose iAUC (OGTT)

Insulin therapy shows a moderate positive evidence signal for improving Glucose iAUC (OGTT) across the studied comparisons.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Resistance training

Resistance training → 2-hour plasma glucose

Resistance training has a small positive evidence signal for 2-hour plasma glucose, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Lifestyle intervention for prediabetes

Lifestyle intervention for prediabetes → Fasting blood sugar (FBS)

Lifestyle intervention for prediabetes has a small positive evidence signal for Fasting blood sugar (FBS), but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Mediterranean diet

Mediterranean diet → Fasting Plasma Glucose (FPG)

Mediterranean diet shows a moderate positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Low-carbohydrate diet

Low-carbohydrate diet → Fasting Plasma Glucose (FPG)

Low-carbohydrate diet shows a strong positive evidence signal for improving Fasting Plasma Glucose (FPG) across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier