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Choose an intervention dossier to evaluate the supplied synthesis and supporting evidence.
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
62 of 62 dossiers shown
Metformin + glimepiride → HbA1c
Metformin + glimepiride shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Multispecies probiotic supplementation → HbA1c
Multispecies probiotic supplementation shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Pioglitazone → Proportion achieving HbA1c <7.0%
Pioglitazone shows a moderate positive evidence signal for improving Proportion achieving HbA1c <7.0% across the studied comparisons.
Standard diet → HbA1c
Standard diet shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Calorie restriction → HbA1c
Calorie restriction shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Empagliflozin → HbA1c
Empagliflozin shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Basal insulin → HbA1c
Basal insulin has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Animal Protein Diet → HbA1c
Animal Protein Diet shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Pioglitazone → HbA1c
Pioglitazone shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) → HbA1c
Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Gastric bypass → HbA1c
Gastric bypass shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Liraglutide → HbA1c
Liraglutide shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Metformin → HbA1c
Metformin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Usual care → HbA1c
Usual care has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Semaglutide → HbA1c
Semaglutide shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Taichi plus resistance band training → HbA1c
Taichi plus resistance band training shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Control Group Usual Activity → HbA1c
Control Group Usual Activity has not shown a clear effect on HbA1c in the available evidence.
Mediterranean diet → HbA1c
Mediterranean diet shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Aerobic exercise → HbA1c
Aerobic exercise shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Dapagliflozin → HbA1c
Dapagliflozin shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Lifestyle intervention for prediabetes → HbA1c
Lifestyle intervention for prediabetes shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Freestyle Libre 1 FGM use → HbA1c
Freestyle Libre 1 FGM use has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Time-Restricted Eating (TRE) → HbA1c
Time-Restricted Eating (TRE) has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Melatonin → HbA1c
Melatonin has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Insulin degludec → HbA1c
Insulin degludec shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Structured multidisciplinary case management → HbA1c
Structured multidisciplinary case management shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Mobile app for diabetes self-management → HbA1c
Mobile app for diabetes self-management shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Curcumin supplementation → HbA1c
Curcumin supplementation shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Exercise therapy → HbA1c
Exercise therapy shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
SRP + OHI → HbA1c
SRP + OHI has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Dipeptidyl peptidase-4 inhibitors → HbA1c
Dipeptidyl peptidase-4 inhibitors shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Low-carbohydrate diet → HbA1c
Low-carbohydrate diet shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
SMS text messaging behavioral intervention for health promotion → HbA1c
SMS text messaging behavioral intervention for health promotion has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Peer-support lifestyle program → HbA1c
Peer-support lifestyle program shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Vitamin D supplementation → HbA1c
Vitamin D supplementation shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Insulin therapy → HbA1c
Insulin therapy shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
SGLT2 inhibitors → HbA1c
SGLT2 inhibitors shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Intermittent Fasting (IF) → HbA1c
Intermittent Fasting (IF) shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Complex lifestyle intervention → HbA1c
Complex lifestyle intervention shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Tirzepatide → HbA1c
Tirzepatide shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Hybrid closed-loop system → HbA1c
Hybrid closed-loop system shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Continuous glucose monitoring → HbA1c
Continuous glucose monitoring shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Non-surgical periodontal treatment → HbA1c
Non-surgical periodontal treatment shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Canagliflozin → HbA1c
Canagliflozin shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Sitagliptin → HbA1c
Sitagliptin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Sleeve gastrectomy → HbA1c
Sleeve gastrectomy shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
WeChat-delivered medical nutrition therapy (WeMNT) → HbA1c
WeChat-delivered medical nutrition therapy (WeMNT) shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
DSMES → HbA1c
DSMES shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
mHealth diabetes support intervention → HbA1c
mHealth diabetes support intervention shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Intensive lifestyle intervention for type 2 diabetes remission → HbA1c
Intensive lifestyle intervention for type 2 diabetes remission shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Very-low-calorie ketogenic diet → HbA1c
Very-low-calorie ketogenic diet shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Instructional WhatsApp group for diabetes self-care → HbA1c
Instructional WhatsApp group for diabetes self-care shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
High-intensity interval exercise → HbA1c
High-intensity interval exercise shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Resistance training → HbA1c
Resistance training shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Glimepiride → HbA1c
Glimepiride shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Remote multiprofessional educational program → HbA1c
Remote multiprofessional educational program shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Low-fat diet → HbA1c
Low-fat diet has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
Rama Diabetes Care app → HbA1c
Rama Diabetes Care app has not shown a clear effect on HbA1c in the available evidence.
Dulaglutide → HbA1c
Dulaglutide shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Self-monitoring of blood glucose → HbA1c
Self-monitoring of blood glucose shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.
Moderate continuous exercise → HbA1c
Moderate continuous exercise shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
