Moderate EvidenceModerate Evidence
Metformin
Evidence related to metformin therapies in diabetes studies.
- Studies
- 39
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cFasting Plasma Glucose (FPG)Body weight
Intervention Evidence
Intervention Evidence
Explore treatments, medications, devices, dietary approaches, and other interventions studied in diabetes research.
818
Interventions
Distinct interventions represented in the evidence index
28
Intervention Groups
Backend-defined intervention groups with evidence coverage
1,283
Research Studies
Active research documents analyzed in the evidence index
6,830
Evidence Relationships
Intervention-outcome relationships with scored evidence
2,086
Outcomes
Distinct outcomes measured across intervention evidence
Dediabetes organizes diabetes interventions by evidence strength, outcomes studied, research coverage, and validated evidence relationships.
Featured Interventions
Moderate EvidenceModerate Evidence
GLP-1 Receptor Agonists
Evidence related to GLP-1 receptor agonist therapies in diabetes studies.
- Studies
- 77
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cBody weightBMI
Moderate EvidenceModerate Evidence
Liraglutide
Evidence related to liraglutide and liraglutide-containing intervention regimens in diabetes studies.
- Studies
- 25
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cBody weightSystolic blood pressure
Moderate EvidenceModerate Evidence
Insulin Therapies
Evidence related to insulin therapies in diabetes studies.
- Studies
- 35
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cTime in rangeTotal daily insulin dose
Moderate EvidenceModerate Evidence
SGLT2 Inhibitors
Evidence related to SGLT2 inhibitor therapies in diabetes studies.
- Studies
- 41
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cFasting Plasma Glucose (FPG)Body weight
Moderate EvidenceModerate Evidence
DPP-4 Inhibitors
Evidence related to DPP-4 inhibitor therapies in diabetes studies.
- Studies
- 25
- Evidence
- Moderate Evidence
Featured outcomes
HbA1cCoefficient of variationBody weight
What's New in Intervention Evidence
May 1, 2026
Psychoeducational Program Improves T1D Literacy in Schools
Relevant to 2 evidence relationships in this category.
May 1, 2026
Semaglutide reduces insulin doses in type 1 diabetes
Relevant to 3 evidence relationships in this category.
April 22, 2026
Online education improves glycemic control in type 2 diabetes management
Relevant to 5 evidence relationships in this category.
April 6, 2026
Exercise training improves cognitive function and balance in type 2 diabetes
Relevant to 4 evidence relationships in this category.
April 5, 2026
Mediterranean Ketogenic Diet Shows Comparable Weight Loss to VLCKD
Relevant to 10 evidence relationships in this category.
March 13, 2026
Nimba Amalakyadi Improves Glycemic Control in Type 2 Diabetes
Relevant to 2 evidence relationships in this category.
March 1, 2026
Corticosteroids may help manage cytokine release syndrome during teplizumab therapy
Relevant to 4 evidence relationships in this category.
February 24, 2026
Canagliflozin improves myocardial fibrosis in type 2 diabetes
Relevant to 4 evidence relationships in this category.
Explore Interventions by Category
Supplements
102Evidence for interventions in Supplements.
Diabetic NeuropathyStrong
MelatoninStrong
Devices & Technology
75Evidence for interventions in Devices & Technology.
Diabetes TechnologyStrong
Diabetes TechnologyStrong
Diabetes TechnologyStrong
Diabetes TechnologyStrong
Behavioral & Lifestyle
205Evidence for interventions in Behavioral & Lifestyle.
Explore categoryMedications
177Evidence for interventions in Medications.
GLP-1 Receptor AgonistsStrong
Diet and Nutrition
140Evidence for interventions in Diet and Nutrition.
Explore categoryPhysical Activity
34Evidence for interventions in Physical Activity.
Explore categoryControl
15Evidence for interventions in Control.
Explore categoryProcedures
34Evidence for interventions in Procedures.
Bariatric ProceduresStrong
Bariatric ProceduresStrong
Most Validated Intervention-Outcome Relationships
Top-ranked relationships with available EvidenceScore™ and ConsistencyScore™ signals.
Supporting studies: Based on 22 studies
Explore evidenceSupporting studies: Based on 15 studies
Explore evidenceSupporting studies: Based on 11 studies
Explore evidenceSupporting studies: Based on 20 studies
Explore evidenceSupporting studies: Based on 11 studies
Explore evidenceSupporting studies: Based on 44 studies
Explore evidenceSupporting studies: Based on 21 studies
Explore evidenceSupporting studies: Based on 18 studies
Explore evidenceEvidence by Intervention and Outcome Groups
| Intervention group | Featured outcome group | EvidenceScore™ | Studies | Relationships | Action |
|---|---|---|---|---|---|
| Diabetes Self-Management Education and Support (DSMES) Programs | Fasting Glucose | Strong | 84 | 210 | Browse |
| Insulin Delivery Systems | HbA1c | Strong | 56 | 64 | Browse |
| Insulin Therapies | HbA1c | Strong | 34 | 58 | Browse |
| GLP-1 Receptor Agonists | HbA1c | Strong | 83 | 168 | Browse |
| SGLT2 Inhibitors | HbA1c | Strong | 38 | 87 | Browse |
| Sulfonylureas | HbA1c | Strong | 10 | 24 | Browse |
| Probiotics and Synbiotics | Adipokine and Angiogenic Markers | Strong | 16 | 56 | Browse |
| DPP-4 Inhibitors | HbA1c | Strong | 22 | 53 | Browse |
| Metformin Therapies | Fasting Glucose | Strong | 33 | 44 | Browse |
| Low-Carbohydrate Diet Education | Insulin Resistance | Strong | 39 | 65 | Browse |
| Aerobic Exercise | Body Composition | Strong | 32 | 61 | Browse |
| Ketogenic Diets | Body Weight | Strong | 13 | 48 | Browse |
Diabetes Self-Management Education and Support (DSMES) Programs
Fasting Glucose
- EvidenceScore™
- Strong
- Studies
- 84
210 relationships
Browse evidenceInsulin Delivery Systems
HbA1c
- EvidenceScore™
- Strong
- Studies
- 56
64 relationships
Browse evidenceInsulin Therapies
HbA1c
- EvidenceScore™
- Strong
- Studies
- 34
58 relationships
Browse evidenceGLP-1 Receptor Agonists
HbA1c
- EvidenceScore™
- Strong
- Studies
- 83
168 relationships
Browse evidenceSGLT2 Inhibitors
HbA1c
- EvidenceScore™
- Strong
- Studies
- 38
87 relationships
Browse evidenceSulfonylureas
HbA1c
- EvidenceScore™
- Strong
- Studies
- 10
24 relationships
Browse evidenceProbiotics and Synbiotics
Adipokine and Angiogenic Markers
- EvidenceScore™
- Strong
- Studies
- 16
56 relationships
Browse evidenceDPP-4 Inhibitors
HbA1c
- EvidenceScore™
- Strong
- Studies
- 22
53 relationships
Browse evidenceMetformin Therapies
Fasting Glucose
- EvidenceScore™
- Strong
- Studies
- 33
44 relationships
Browse evidenceLow-Carbohydrate Diet Education
Insulin Resistance
- EvidenceScore™
- Strong
- Studies
- 39
65 relationships
Browse evidenceAerobic Exercise
Body Composition
- EvidenceScore™
- Strong
- Studies
- 32
61 relationships
Browse evidenceKetogenic Diets
Body Weight
- EvidenceScore™
- Strong
- Studies
- 13
48 relationships
Browse evidenceAll Interventions
Browse 818 interventions represented in the evidence graph.
Showing 1-25 of 818 interventions
| Intervention | Category | Group | EvidenceScore™ | Studies | Outcomes | Action |
|---|---|---|---|---|---|---|
| Low-carbohydrate diet | Behavioral & Lifestyle | Low-Carbohydrate Diet Education | 86/100 | 36 | 114 | |
| Lifestyle intervention for prediabetes | Behavioral & Lifestyle | Gestational Diabetes | 87/100 | 40 | 103 | |
| Semaglutide | Medications | GLP-1 Receptor Agonists | 88/100 | 36 | 101 | |
| Continuous glucose monitoring | Devices & Technology | Insulin Delivery Systems | 88/100 | 30 | 92 | |
| Metformin | Medications | Metformin Therapies | 85/100 | 35 | 90 | |
| Vitamin D supplementation | Supplements | Diabetic Neuropathy | 82/100 | 21 | 81 | |
| Aerobic exercise | Physical Activity | Aerobic Exercise | 83/100 | 24 | 80 | |
| Liraglutide | Medications | GLP-1 Receptor Agonists | 84/100 | 23 | 80 | |
| Mediterranean diet | Diet and Nutrition | Cardiometabolic Risk | 85/100 | 20 | 80 | |
| Hybrid closed-loop system | Devices & Technology | Insulin Delivery Systems | 88/100 | 31 | 71 | |
| Exercise therapy | Physical Activity | Cardiometabolic Risk | 83/100 | 21 | 69 | |
| DSMES | Behavioral & Lifestyle | Diabetes Self-Management Education and Support (DSMES) Programs | 86/100 | 19 | 67 | |
| Insulin therapy | Medications | Insulin Therapies | 83/100 | 21 | 64 | |
| Empagliflozin | Medications | SGLT2 Inhibitors | 85/100 | 20 | 63 | |
| Resistance training | Physical Activity | Cardiometabolic Risk | 84/100 | 20 | 62 | |
| Usual care | Behavioral & Lifestyle | 86/100 | 36 | 61 | ||
| SMS text messaging behavioral intervention for health promotion | Behavioral & Lifestyle | Diabetes Self-Management Education and Support (DSMES) Programs | 83/100 | 17 | 60 | |
| Time-Restricted Eating (TRE) | Diet and Nutrition | Dietary Patterns | 83/100 | 11 | 60 | |
| Complex lifestyle intervention | Behavioral & Lifestyle | Diabetes Self-Management Education and Support (DSMES) Programs | 79/100 | 8 | 56 | |
| Tirzepatide | Medications | GLP-1 Receptor Agonists | 83/100 | 18 | 53 | |
| High-intensity interval exercise | Physical Activity | Insulin Resistance | 83/100 | 13 | 53 | |
| Dapagliflozin | Medications | SGLT2 Inhibitors | 82/100 | 13 | 52 | |
| Very-low-calorie ketogenic diet | Diet and Nutrition | Ketogenic Diets | 79/100 | 11 | 52 | |
| Gastric bypass | Procedures | Bariatric Procedures | 79/100 | 9 | 46 | |
| Exenatide | Medications | GLP-1 Receptor Agonists | 79/100 | 7 | 45 |
Low-carbohydrate diet
Behavioral & Lifestyle - Low-Carbohydrate Diet Education
- EvidenceScore™
- 86/100
- Studies
- 36
114 outcomes
Lifestyle intervention for prediabetes
Behavioral & Lifestyle - Gestational Diabetes
- EvidenceScore™
- 87/100
- Studies
- 40
103 outcomes
Semaglutide
Medications - GLP-1 Receptor Agonists
- EvidenceScore™
- 88/100
- Studies
- 36
101 outcomes
Continuous glucose monitoring
Devices & Technology - Insulin Delivery Systems
- EvidenceScore™
- 88/100
- Studies
- 30
92 outcomes
Metformin
Medications - Metformin Therapies
- EvidenceScore™
- 85/100
- Studies
- 35
90 outcomes
Vitamin D supplementation
Supplements - Diabetic Neuropathy
- EvidenceScore™
- 82/100
- Studies
- 21
81 outcomes
Aerobic exercise
Physical Activity - Aerobic Exercise
- EvidenceScore™
- 83/100
- Studies
- 24
80 outcomes
Liraglutide
Medications - GLP-1 Receptor Agonists
- EvidenceScore™
- 84/100
- Studies
- 23
80 outcomes
Mediterranean diet
Diet and Nutrition - Cardiometabolic Risk
- EvidenceScore™
- 85/100
- Studies
- 20
80 outcomes
Hybrid closed-loop system
Devices & Technology - Insulin Delivery Systems
- EvidenceScore™
- 88/100
- Studies
- 31
71 outcomes
Exercise therapy
Physical Activity - Cardiometabolic Risk
- EvidenceScore™
- 83/100
- Studies
- 21
69 outcomes
DSMES
Behavioral & Lifestyle - Diabetes Self-Management Education and Support (DSMES) Programs
- EvidenceScore™
- 86/100
- Studies
- 19
67 outcomes
Insulin therapy
Medications - Insulin Therapies
- EvidenceScore™
- 83/100
- Studies
- 21
64 outcomes
Empagliflozin
Medications - SGLT2 Inhibitors
- EvidenceScore™
- 85/100
- Studies
- 20
63 outcomes
Resistance training
Physical Activity - Cardiometabolic Risk
- EvidenceScore™
- 84/100
- Studies
- 20
62 outcomes
Usual care
Behavioral & Lifestyle
- EvidenceScore™
- 86/100
- Studies
- 36
61 outcomes
SMS text messaging behavioral intervention for health promotion
Behavioral & Lifestyle - Diabetes Self-Management Education and Support (DSMES) Programs
- EvidenceScore™
- 83/100
- Studies
- 17
60 outcomes
Time-Restricted Eating (TRE)
Diet and Nutrition - Dietary Patterns
- EvidenceScore™
- 83/100
- Studies
- 11
60 outcomes
Complex lifestyle intervention
Behavioral & Lifestyle - Diabetes Self-Management Education and Support (DSMES) Programs
- EvidenceScore™
- 79/100
- Studies
- 8
56 outcomes
Tirzepatide
Medications - GLP-1 Receptor Agonists
- EvidenceScore™
- 83/100
- Studies
- 18
53 outcomes
High-intensity interval exercise
Physical Activity - Insulin Resistance
- EvidenceScore™
- 83/100
- Studies
- 13
53 outcomes
Dapagliflozin
Medications - SGLT2 Inhibitors
- EvidenceScore™
- 82/100
- Studies
- 13
52 outcomes
Very-low-calorie ketogenic diet
Diet and Nutrition - Ketogenic Diets
- EvidenceScore™
- 79/100
- Studies
- 11
52 outcomes
Gastric bypass
Procedures - Bariatric Procedures
- EvidenceScore™
- 79/100
- Studies
- 9
46 outcomes
Exenatide
Medications - GLP-1 Receptor Agonists
- EvidenceScore™
- 79/100
- Studies
- 7
45 outcomes