Elderly patient with long-standing diabetes achieved sustained insulin independence through lifestyle intervention
Key takeaway:
A 78-year-old man with 40 years of type 2 diabetes and 31 years of insulin therapy discontinued insulin and maintained glycemic control for 77 months after an intensive lifestyle intervention.
Study at a glance
What was studied
Intensive lifestyle intervention for insulin discontinuation in an elderly patient with long-standing type 2 diabetes.
Study type
non-randomized clinical trial (non-RCT or NRCT)
duration
Long-Term (> 12 mo)
Intervention
Multidisciplinary lifestyle intervention for type 2 diabetes remission
Outcomes
Diabetes medication use, HbA1c, Body weight, BMI, Triglycerides, HDL cholesterol, C-reactive protein, Fasting insulin levels
Funding
Non-industry sponsored
Main effects
Insulin discontinuation: Insulin withdrawn in first month and remained discontinued at 77-month follow-up
HbA1c stable: HbA1c decreased from 7.0% to 6.6% at 10 months and maintained at 6.6% at 77 months
Weight and metabolic markers improved: Weight, BMI, triglycerides, HDL, and hs-CRP all improved
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) |  BMI (Weight & Anthropometrics) | Decrease | Strong |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) | Body weight (Weight & Anthropometrics) | Decrease | Strong |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) |  C-reactive protein (Metabolic Health) | Decrease | Mixed |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) |  Diabetes medication use (Adherence & Engagement) | Decrease | Strong |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) | Fasting insulin levels (Metabolic Health) | Uncertain | Mixed |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) |  HbA1c (Glycemic Control) | Decrease | Mixed |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) | HDL cholesterol (Metabolic Health) | Increase | Mixed |
Multidisciplinary lifestyle intervention for type 2 diabetes remission (Behavioral & Lifestyle) | Triglycerides (Metabolic Health) | Decrease | Mixed |
Unlock Full Evidence Analysis
Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
Evidence Suggest
- This is a single-patient case report describing outcomes in one 78-year-old man.
- The intervention included multiple simultaneous components, making it impossible to isolate which elements contributed to outcomes.
- The patient continued oral diabetes medication (gliclazide) throughout follow-up.
- Preserved C-peptide and fasting insulin at 77 months indicate residual beta-cell function.
Who this applies to
One 78-year-old man with 40-year history of type 2 diabetes
Keep in Mind
This is a case report of one patient, not a controlled trial.
Between the Lines
- Single-patient case report with no control or comparison group.
- Multiple intervention components introduced simultaneously.
- Continuation of oral diabetes medication (gliclazide) throughout follow-up period.
- No way to determine if outcomes were due to the intervention or natural disease variability.
Unlock Full Analysis
Create a free account to unlock the bias score, detailed effectiveness analysis, and clinical outcomes for this study.
Journal Reference
Sustained Insulin Independence Following Lifestyle Intervention in a 78-Year-Old Patient With Long-Standing Type 2 Diabetes: A Six-Year Follow-Up Case Report. Cureus. 2026;[publication details not available]. PMCID:PMC13181349
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Multidisciplinary lifestyle intervention for type 2 diabetes remission and BMI, Multidisciplinary lifestyle intervention for type 2 diabetes remission and Body weight.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
BMI Evidence Hub
All studies measuring BMI
Measures BMI as a key outcome.
Body weight Evidence Hub
All studies measuring Body weight
Measures Body weight as a key outcome.
Multidisciplinary lifestyle intervention for type 2 diabetes remission Evidence Hub
All studies on Multidisciplinary lifestyle intervention for type 2 diabetes remission
Contributes to Multidisciplinary lifestyle intervention for type 2 diabetes remission evidence base.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Multidisciplinary lifestyle intervention for type 2 diabetes remission and BMI
2 results
All studies on Multidisciplinary lifestyle intervention for type 2 diabetes remission and Body weight
2 results
All studies on Multidisciplinary lifestyle intervention for type 2 diabetes remission
2 results
All studies measuring BMI
2 results
All studies measuring Body weight
2 results
Questions this evidence helps answer
Key clinical and research questions this study contributes to.
Does multidisciplinary lifestyle intervention for type 2 diabetes remission improve BMI?
Based on connected evidence for Multidisciplinary lifestyle intervention for type 2 diabetes remission and BMI.
Does multidisciplinary lifestyle intervention for type 2 diabetes remission affect Body weight in people with diabetes?
Exploring evidence on Multidisciplinary lifestyle intervention for type 2 diabetes remission and Body weight outcomes.
No ads. No tracking.
Focused on evidence, not advertising.
Secure & private
Your data is always protected.
Always up to date
New studies added every day.