Curcumin plus piperine may improve sleep and mood in diabetic retinopathy
Key takeaway:
In adults with non-proliferative diabetic retinopathy, 12 weeks of curcumin plus piperine improved sleep quality and mood scores and produced small reductions in BMI and waist circumference versus placebo.
Study at a glance
What was studied
A 12-week curcumin-piperine supplementation trial in non-proliferative diabetic retinopathy.
Study type
Randomized Controlled Trials (RCTs)
duration
Short-Term (≤3 mo)
Intervention
Curcumin plus piperine
Outcomes
BMI, Waist circumference, Sleep quality, Depression score, Anxiety score, Stress score
Funding
Industry sponsored
Main effects
Sleep quality score improved (PSQI ↓) versus placebo
Depression, anxiety, and stress scores improved versus placebo
BMI and waist circumference showed small favorable decreases
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Curcumin plus piperine (Supplements) |  Anxiety score (Patient-Reported) | Decrease | Mixed |
Curcumin plus piperine (Supplements) |  BMI (Weight & Anthropometrics) | Decrease | Limited |
Curcumin plus piperine (Supplements) | Depression score (Patient-Reported) | Decrease | Mixed |
Curcumin plus piperine (Supplements) | Sleep quality (Patient-Reported) | Decrease | Mixed |
Curcumin plus piperine (Supplements) | Stress score (Patient-Reported) | Decrease | Mixed |
Curcumin plus piperine (Supplements) | Waist circumference (Weight & Anthropometrics) | Decrease | Limited |
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Evidence Suggest
- Randomized, double-blind, placebo-controlled design supports internal validity.
- Intention-to-treat analysis included all 60 randomized participants.
- Anthropometric effects were statistically significant but small in magnitude.
Who this applies to
Adults aged 30-65 with non-proliferative diabetic retinopathy
Keep in Mind
The trial duration was 12 weeks, so long-term effects are uncertain.
Between the Lines
- Small sample size
- Single-center trial
- Short follow-up duration
- Single dose tested without dose-response analysis
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Journal Reference
Amini S, Dehghani A, Sahebkar A, et al. The Effect of Curcumin Plus Piperine on Mental Health Status, Sleep Quality, and Anthropometric Indices in Patients with Non-Proliferative Diabetic Retinopathy: A Randomized Double-Blind Placebo-Controlled Trial. Int J Prev Med. 2026;17:14. doi:10.4103/ijpvm.ijpvm_276_23
Sources
Ranked by clinical relevance and evidence quality.
Key References
Most relevant evidence and guidance related to this research.
AACE Releases 2023 Type 2 Diabetes Management Algorithm to Support Clinical Decision Making | American Association of Clinical Endocrinology
Abaloparatide Followed by Alendronate Shows Promising Results for Women With Osteoporosis, T2D | American Association of Clinical Endocrinology
Connecting the Dots: Diabetes, CKD, and CVD Pathways | American Association of Clinical Endocrinology
Supporting Evidence
Supporting evidence and related resources.
Episode 39: AACE 2023 Updated Comprehensive Type 2 Diabetes Management Algorithm | American Association of Clinical Endocrinology
Episode 74: 2026 AACE Algorithm for Management of Adults with Type 2 Diabetes: Key Updates and Clinical Insights | American Association of Clinical Endocrinology
American Diabetes Association Standards of Care in Diabetes—2026
World Health Organization: Diabetes
National Eye Institute: Diabetic Retinopathy
Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
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