Allium hookeri extract reduces HbA1c levels in prediabetic adults
Punto clave:
An 8-week trial in 30 Korean adults with prediabetes found that Allium hookeri extract supplementation significantly reduced HbA1c levels compared to placebo, suggesting potential benefits for glycemic control.
Estudio de un vistazo
Qué se estudió
Effects of Allium hookeri extract on blood sugar control in adults with prediabetes
Tipo de estudio
Randomized Controlled Trials (RCTs)
duration
Short-Term (≤3 mo)
Intervención
Allium hookeri extract
Resultados
HbA1c, Fasting Plasma Glucose, Glucose incremental area under curve (iAUC), Fasting insulin levels, Total cholesterol, Triglycerides, LDL cholesterol, HDL cholesterol
Financiamiento
Financiado por la industria
mainEffects
HbA1c ↓ (decreased from baseline compared to placebo)
1-hour post-OGTT glucose ↑ in placebo group (significant group difference)
Glucose iAUC ↑ in placebo group (significant group difference)
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Allium hookeri extract (Supplements) |  Fasting insulin levels (Metabolic Health) | Uncertain | Limited |
Allium hookeri extract (Supplements) |  Fasting Plasma Glucose (Glycemic Control) | Mixed | Mixed |
Allium hookeri extract (Supplements) |  Glucose incremental area under curve (iAUC) (Clinical Outcomes) | Mixed | Mixed |
Allium hookeri extract (Supplements) | HbA1c (Glycemic Control) | Decrease | Mixed |
Allium hookeri extract (Supplements) | HDL cholesterol (Metabolic Health) | Uncertain | Limited |
Allium hookeri extract (Supplements) | LDL cholesterol (Metabolic Health) | Uncertain | Limited |
Allium hookeri extract (Supplements) | Total cholesterol (Metabolic Health) | Uncertain | Limited |
Allium hookeri extract (Supplements) | Triglycerides (Metabolic Health) | Uncertain | Limited |
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Evidence Suggest
- HbA1c decreased significantly in the Allium hookeri group compared to placebo after 8 weeks
- The supplement was well tolerated with no serious adverse events
- Changes in postprandial glucose response showed significant group differences, though partly due to placebo group increases
Who this applies to
This study was conducted in Korean adults aged 54 years on average with prediabetes (fasting plasma glucose 100-126 mg/dL) and average BMI of 25.8 kg/m². Results may be most relevant to Asian populations with prediabetes who are otherwise healthy and not taking diabetes medications.
Keep in Mind
This is a small pilot study that needs confirmation in larger, longer trials before clinical recommendations can be made. The supplement has not been tested in people with diagnosed diabetes or those already taking diabetes medications. The crossover design may have limitations for assessing HbA1c, which reflects 3-month average glucose levels. Individual responses may vary, and the supplement should not replace standard medical care for prediabetes.
Between the Lines
- Very small sample size (30 enrolled, 22 completed)
- Short 8-week duration limits assessment of long-term effects
- Some glucose findings driven by unexpected placebo group increases
- Limited to Korean population with prediabetes
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Referencia de la Revista
Park SH, Bae UJ, Choi EK, et al. A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes. BMC Complement Med Ther. 2020;20:211. doi:10.1186/s12906-020-03005-3
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